ERP27 Antibody, HRP conjugated

Code CSB-PA842657LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ERP27 Polyclonal antibody
Uniprot No.
Target Names
ERP27
Alternative Names
C12orf46 antibody; Chromosome 12 open reading frame 46 antibody; Endoplasmic reticulum protein 27 antibody; Endoplasmic reticulum protein 27 kDa antibody; Endoplasmic reticulum resident protein 27 antibody; Endoplasmic reticulum resident protein ERp27 antibody; ER protein 27 antibody; ERp 27 antibody; ERp27 antibody; ERP27_HUMAN antibody; FLJ32115 antibody; PDIA8 antibody; Protein disulfide isomerase family A; member 8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Endoplasmic reticulum resident protein 27 protein (26-273AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response.
Gene References into Functions
  1. High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility PMID: 23234573
  2. ERp27 is able to distinguish between folded and unfolded substrates, only interacting with the latter and presenting them to for catalysis. PMID: 23192347
  3. ERp27 is bound by ERp57 both in vitro and in vivo by a similar mechanism by which ERp57 binds calreticulin PMID: 16940051
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Protein disulfide isomerase family
Database Links

HGNC: 26495

OMIM: 610642

KEGG: hsa:121506

STRING: 9606.ENSP00000266397

UniGene: Hs.162143

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